GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| THYM | cis | rs2243480 | 1 | rs1638734 | chr7:66097539 | CCT6P1 | chr7:65216092-65228661:+ | 0.59 | 4.86 | 4.58E-6 | Diabetic kidney disease |
| THYM | cis | rs1577917 | 1 | rs16876529 | chr6:86591202 | SNHG5 | chr6:86386726-86388451:- | -0.57 | -7.62 | 1.9E-11 | Response to antipsychotic treatment |
| THYM | cis | rs7223966 | 1 | rs16947005 | chr17:61702989 | TCAM1P | chr17:61934376-61941738:+ | 0.54 | 4.54 | 1.65E-5 | Body mass index |
| THYM | cis | rs7223966 | 1 | rs16947014 | chr17:61719032 | TCAM1P | chr17:61934376-61941738:+ | -0.54 | -4.33 | 3.63E-5 | Body mass index |
| THYM | cis | rs7223966 | 1 | rs16947042 | chr17:61766457 | TCAM1P | chr17:61934376-61941738:+ | -0.52 | -4.32 | 3.77E-5 | Body mass index |
| THYM | cis | rs17761864 | 1 | rs16952009 | chr17:2102437 | SRR | chr17:2207248-2228553:+ | -0.45 | -4.91 | 3.8E-6 | Esophageal cancer (squamous cell) |
| THYM | cis | rs2243480 | 1 | rs1701750 | chr7:65467145 | CCT6P1 | chr7:65216092-65228661:+ | 0.6 | 4.98 | 2.86E-6 | Diabetic kidney disease |
| THYM | cis | rs2243480 | 1 | rs1701758 | chr7:65470201 | CCT6P1 | chr7:65216092-65228661:+ | 0.6 | 4.98 | 2.86E-6 | Diabetic kidney disease |
| THYM | cis | rs7565981 | 1 | rs17024770 | chr2:101421316 | PDCL3 | chr2:101179418-101193201:+ | 0.55 | 4.47 | 2.15E-5 | Creutzfeldt-Jakob disease (variant) |
| THYM | cis | rs9815354 | 1 | rs17061431 | chr3:41792655 | ULK4 | chr3:41288091-42003660:- | 1 | 10.61 | 8.33E-18 | Diastolic blood pressure |
| THYM | cis | rs9815354 | 1 | rs17062109 | chr3:41810364 | ULK4 | chr3:41288091-42003660:- | 0.99 | 10.93 | 1.72E-18 | Diastolic blood pressure |
| THYM | cis | rs9815354 | 1 | rs17063584 | chr3:41861463 | ULK4 | chr3:41288091-42003660:- | 1 | 10.81 | 3.16E-18 | Diastolic blood pressure |
| THYM | cis | rs9815354 | 1 | rs17063599 | chr3:41861676 | ULK4 | chr3:41288091-42003660:- | 1 | 10.81 | 3.16E-18 | Diastolic blood pressure |
| THYM | cis | rs9815354 | 1 | rs17063649 | chr3:41863406 | ULK4 | chr3:41288091-42003660:- | 1 | 10.81 | 3.16E-18 | Diastolic blood pressure |
| THYM | cis | rs9815354 | 1 | rs17064124 | chr3:41890803 | ULK4 | chr3:41288091-42003660:- | 1.02 | 11.47 | 1.22E-19 | Diastolic blood pressure |